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Mitochondrial Content Inducer, BRD6897-Calbiochem

品牌
Sigma-Aldrich
货号
5.05984
包装型号
规格纯度
参考价格
2486.58 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.

生化/生理作用

Cell permeable: yes
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Kitami, T., et al. 2012. PLoS ONE7, e33755.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C25H21N3O2S2
分子量459.58

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 10 mg/mL
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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