产品说明
一般描述
Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 also regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It appears to Inhibit caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Further understanding in how Bcl-2 functions and interacts with other proteins to promote or inhibit apoptosis may lead to new treatments for cancer, neurological disorders and autoimmune diseases.
特异性
Antibody recognizes Bcl-2.
免疫原
KLH-conjugated, synthetic peptide corresponding to human Bcl-2
应用
Research Sub Category
BCL2 & Inhibition
This Milli-Mark Bcl-2 antibody is validated for use in Flow for the detection of the Milli-Mark Bcl-2 protein.
Research Category
Apoptosis & Cancer
质量
Evaulated by flow cytometery using Jurkat cells.
目标描述
26 kDa Calculated
外形
Purified mouse monoclonal IgG2a conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Protein G Purified
储存及稳定性
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
分析说明
Control
Jurkat Cells
法律信息
ALEXA FLUOR is a registered trademark of Life Technologies
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
偶联物 | ALEXA FLUOR® 488 |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | AW604, monoclonal |
species reactivity | human |
manufacturer/tradename | Milli-Mark® |
technique(s) | flow cytometry: suitable |
同位素/亚型 | IgG2a |
NCBI登记号 | NP_000624 |
UniProt登记号 | P10415 |
运输 | wet ice |
Gene Information | human ... BCL2(596) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |