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Protein A–Biotin from Staphylococcus aureus

品牌
Sigma-Aldrich
货号
P2165
规格纯度
lyophilized powder
参考价格
2973.76 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Protein A (SpA) is a 42kDa virulence factor produced by Staphylococcus aureus, and is composed of five highly homologous consecutive extracellular Ig-binding domains, namely domains E, D, A, B, and C. This protein is present in both secreted and membrane-associated forms.

特异性

Binds IgG only from most mammals, except rat, goat, and sheep

生化/生理作用

Protein A (SpA) causes B cells death in vitro, by binding to the Fc region of antibody and the Fab regions of the B-cell receptor, thus inhibiting its opsonophagocytosis. This protein is thought to be implicated in the evasion of host immune responses by Staphylococcus aureus, and thus, might be a candidate for vaccine development approaches to prevent severe S. aureus infections. S. aureus is responsible for nosocomial infections as well as a variety of human infections, such as food poisoning, toxic shock syndrome, endocarditis, septicemia, skin infections, soft tissue infections, and bone infections. It is also responsible for bovine and ovine mastitis. SpA typing or DNA sequence analysis of the variable repeat region of protein A gene is useful in determining S. aureus outbreak strains from those strains that are epidemiologically insignificant.

外形

含柠檬酸钠的冻干粉

制备说明

Prepared from P 6031, coupled to biotin by an amide bond through an aminocaproyl spacer.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00132098
NACRESNA.46

产品性质

质量水平300
200
偶联物biotin conjugate
形式lyophilized powder
组成Protein, ≥70% biuret
标记范围3.0-8.0 mol biotin per mol Protein A
储存温度2-8℃

Sigma-Aldrich

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