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Anti-ATF-1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
A7833
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Activating Transcription Factor 1 (ATF1) or TREB-36 is a member of the ATF/ CREB (cAMP response element binding protein) family of basic region leucine-zipper (bZip) DNA-binding proteins. It is encoded by the gene mapped to human chromosome 12q13.12. ATF1 mRNA is expressed in variety of tissues.

特异性

Anti-ATF1 specifically recognizes human ATF1.

免疫原

synthetic peptide corresponding to human ATF-1, N-terminal sequence, amino acids 6-23, conjugated to KLH.

应用

Rabbit Anti-ATF-1 antibody is suitable for western blot applications at 1:500.

生化/生理作用

Activating transcription factor 1 (ATF1) mediates both Ca2+ and cAMP responses at several levels. It binds to the tax-responsive element (TRE1) of the human T-cell lymphotropic virus type-I (HTLV-1). ATF1 is detectable in metastatic melanoma cells and seems to contribute to their survival. A chimeric protein composed of the N-terminal domain of EWS (Ewing sarcoma oncogene) linked to the bZip domain of ATF1 is implicated in the rare malignant clear cell sarcoma of tendon sheath and aponeuroses (malignant melanoma of soft parts).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For prolonged storage, freeze in working aliquots at -20 ℃. Repeated freezing and thawing is not recom-mended. Storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01092262

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 35-38 kDa
species reactivityhuman
technique(s)microarray: suitable
western blot (chemiluminescent): 1:500 using whole cell extract of human Jurkat acute T cell leukemia cells
UniProt登记号P18846
运输dry ice
储存温度−20℃
Gene Informationhuman ... ATF1(466)

Sigma-Aldrich

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