产品介绍：
产品说明
一般描述
2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.
应用
2′-Deoxycytidine has been used:
- as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
- as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
- to study the role of autophagy in response to oncogenes and DNA replication stress
包装
1, 5 g in poly bottle
100, 250, 500 mg in poly bottle
生化/生理作用
2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.
基本信息
| 经验(实验)分子式 | C9H13N3O4 |
| 分子量 | 227.22 |
| Beilstein | 87567 |
| EC 号 | 213-454-1 |
| MDL编号 | MFCD00006547 |
| PubChem化学物质编号 | 24893793 |
| NACRES | NA.51 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥99% (HPLC) |
| 形式 | powder |
| 溶解性 | water: 50 mg/mL, clear, colorless to very faintly yellow |
| 储存温度 | −20℃ |
| SMILES string | NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2 |
| InChI | 1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 |
| InChI key | CKTSBUTUHBMZGZ-SHYZEUOFSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
