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2′-Deoxycytidine

2'-脱氧胞苷

品牌
Sigma-Aldrich
CAS
951-77-9
货号
D3897
规格纯度
≥99% (HPLC)
参考价格
684.83 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

应用

2′-Deoxycytidine has been used:

  • as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
  • as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
  • to study the role of autophagy in response to oncogenes and DNA replication stress

包装

1, 5 g in poly bottle
100, 250, 500 mg in poly bottle

生化/生理作用

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

基本信息

经验(实验)分子式C9H13N3O4
分子量227.22
Beilstein87567
EC 号213-454-1
MDL编号MFCD00006547
PubChem化学物质编号24893793
NACRESNA.51

产品性质

质量水平200
生物来源synthetic (organic)
测定≥99% (HPLC)
形式powder
溶解性water: 50 mg/mL, clear, colorless to very faintly yellow
储存温度−20℃
SMILES stringNC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
InChI1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
InChI keyCKTSBUTUHBMZGZ-SHYZEUOFSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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