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Cytochalasin B from Drechslera dematioidea

细胞松弛素B 来源于Drechslera dematioidea

品牌
Sigma-Aldrich
CAS
14930-96-2
货号
C6762
规格纯度
≥98% (HPLC), powder
参考价格
579.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:

  • Disruption of actin filaments and of interaction of actin filaments in solution
  • Inhibition of actin polymerization
  • Inhibition of subunit association and dissociation
Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.

包装

1, 5, 10, 25, 50 mg in serum bottle

生化/生理作用

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

基本信息

经验(实验)分子式C29H37NO5
分子量479.61
Beilstein1096207
EC 号239-000-2
MDL编号MFCD00077704
PubChem化学物质编号24892890
NACRESNA.32

产品性质

质量水平300
测定≥98% (HPLC)
形式powder
颜色 white
溶解性DMSO: 10 mg/mL
作用机制DNA synthesis | interferes
抗生素抗菌谱fungi
储存温度−20℃
SMILES stringC[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI keyGBOGMAARMMDZGR-TYHYBEHESA-N

安全信息

象形图GHS06GHS08
警示用语:Danger
危险声明H300 + H310 + H330 - H361
预防措施声明P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
危险分类Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

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