产品说明
一般描述
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation.
应用
Thymidine phosphorylase has been used in a study to assess TAS-102 treatment in patients with advanced solid tumors. Thymidine phosphorylase has also been used in a study to investigate antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma.
包装
5000 units in glass bottle
生化/生理作用
An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays.
单位定义
One unit will convert 1.0 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per min at pH 7.4 at 25℃.
外形
Solution in 0.5 M potassium phosphate containing 2 mM uracil, 0.02% sodium azide and bovine serum albumin
制备说明
Cloned from E. coli and produced in overexpressing E. coli
基本信息
| 酶学委员会(EC)编号 | 2.4.2.4 ( BRENDA | IUBMB ) |
| MDL编号 | MFCD00132426 |
| NACRES | NA.54 |
产品性质
| 质量水平 | 300 |
| 重组 | expressed in E. coli |
| 形式 | buffered aqueous solution |
| 浓度 | ≥500 units/mL |
| UniProt登记号 | P07650 |
| 储存温度 | 2-8℃ |
| Gene Information | Escherichia coli K12 ... deoA(948901) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
