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Nicotinamide N-Methyltransferase (hNNMT) human

品牌
Sigma-Aldrich
货号
SRP6282
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
参考价格
4424.24 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

外形

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥98% (SDS-PAGE)
形式liquid
分子量 31.7 kDa (263 aa + NT 6xHis-tag)
包装pkg of 1 mg
pkg of 100 μg
pkg of 20 μg
浓度3.42 mg/mL
UniProt登记号P40261
运输dry ice
储存温度−70℃
Gene Informationhuman ... NNMT(4837)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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