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Cathepsin S, Human, Recombinant, E. coli

品牌
Sigma-Aldrich
货号
219343
规格纯度
Cathepsin S, Human, Recombinant, E. coli, is prepared without a tag or fusion protein. A major lysosomal cysteine proteinase with high specific activity.
参考价格
4939.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Note: 1 mU = 1 milliunit.
Recombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase preferentially expressed in macrophages and microglia. Exhibits high specific activity.
Recombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.

包装

25 μg in Plastic ampoule

警告

Toxicity: Harmful (C)

单位定义

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.

外形

In 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.

重悬

Following initial thaw, aliquot and freeze (-70°C).

其他说明

Liuzzo, J.P., et al. 1999. Mol. Med.5, 334.
Riese, R.J., et al. 1998. J. Clin. Invest.101, 2351.
Sukhova, G.K., et al. 1998. J. Clin. Invest.102, 576.
Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol.244, 500.
Xin, X.Q., et al. 1992. Arch. Biochem. Biophys.299, 334.
Kirschke, H., et al. 1989. Biochem. J.264, 467.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

酶学委员会(EC)编号3.4.22.27 ( BRENDA | IUBMB )

产品性质

质量水平100
重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式liquid
specific activity≥30,000 mU/mg protein
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
avoid repeated freeze/thaw cycles
运输wet ice
储存温度−70℃

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H373
预防措施声明P260 - P264 - P270 - P301 + P312 - P314 - P501
危险分类Acute Tox. 4 Oral - STOT RE 2 Oral
靶器官Kidney
储存分类代码10 - Combustible liquids
WGKWGK 1

Sigma-Aldrich

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