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Caco-2 Engineered Control Cells

品牌
Sigma-Aldrich
货号
MTOX1000CC
规格纯度
one vial of frozen cells
参考价格
16672 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The C2BBe1 cells, a sublcone of Caco-2 cells, correspond to ATCC CRL-2101. The C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years).

应用

The Engineered Control cells can be used for drug permeability assays. They may also be used as the control in conjunction with C2BBe1 Transporter Knockout cell lines for drug/transporter interaction studies. Engineered control cells have been used in the in vitro Caco-2 permeability assay. The following posters and articles demonstrate how Caco-2 cells can be used for cell based assays:

Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases

Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes

Caco-2 Transporter Knockout Cell Based Assays

特点和优势

The Caco-2 subclone C2BBe1 cells are ideal for transporter analysis as they express multiple transporters, are human-derived, and grow in a homogenous monolayer that forms tight junctions which is necessary for efflux ratio analysis.

质量

Tested for Mycoplasma, bacterial and fungal content, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.

法律信息

This product is covered under a consumable purchase agreement for one-time use only. For more information:ADME/Tox Cell Lines License

产品性质

生物来源human male colorectal tissue (Source Disease: adenocarcinoma)
形式liquid
储存温度−196℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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