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DNA Methyltransferase Inhibitor-CAS 32675-71-1-Calbiochem

品牌
Sigma-Aldrich
CAS
32675-71-1
货号
260920
规格纯度
The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.
参考价格
3056.54 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
CPG methylase M.Sssl

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Brueckner, B., et al. 2005. Cancer Res.65, 6305.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H14N2O4
分子量334.33

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
效能115 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 100 mg/mL
methanol: soluble
运输ambient
储存温度2-8℃
InChI1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)
InChI keyHPTXLHAHLXOAKV-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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