位置:首页 > 品牌 > Sigma-Aldrich >

GW843682X

品牌
Sigma-Aldrich
CAS
660868-91-7
货号
G2171
规格纯度
≥98% (HPLC), solid
参考价格
1665.43 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

GW843682X has been used as a polo-like kinase-1 (PLK1) inhibitor:

  • to study the influence of PLK1 inhibition on Wee1 (G2 check point kinase), cyclin-dependent protein kinase 1 (Cdc2)–Yp15, expression in melanoma cells
  • to determine if PLK1 inhibition decreased the survival of hamartin and tuberin deficient cells
  • to investigate if inhibitors of PLK1 and aurora kinases have a synergistic antimitotic impact in HeLa cells

包装

1, 5 mg in glass bottle

生化/生理作用

GW843682X is an anti-cancer compound. It can improve the ability of vincristine to promote growth arrest and apoptosis in leukemia cells. GW843682X is capable of disturbing the formation of spindles and terminate mitoses in lung adenocarcinoma cells.
GW843682X is a polo-like kinase-1 (PLK1) and polo-like kinase-3 (PLK3) inhibitor with nanomolar activity. It shows potent inhibition of proliferation of a wide variety of tumor cell lines.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C22H18F3N3O4S
分子量477.46
MDL编号MFCD09971143
PubChem化学物质编号329799898
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 off-white
溶解性DMSO: >10 mg/mL
创始人GlaxoSmithKline
储存温度2-8℃
SMILES stringCOc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC
InChI1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)
InChI keyJSKUWFIZUALZLX-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335 - H413
预防措施声明P261 - P305 + P351 + P338
危险分类Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号