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1-deoxysphinganine

品牌
Avanti
CAS
196497-48-0
货号
860493P
规格纯度
1-deoxysphinganine (m18:0), powder
参考价格
2636.64 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides.

应用

1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells.

生化/生理作用

1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.

包装

5 mL Amber Glass Screw Cap Vial (860493P-1mg)
5 mL Amber Glass Screw Cap Vial (860493P-10mg)

基本信息

经验(实验)分子式C18H39NO
分子量285.51
NACRESNA.25

产品性质

形式powder
包装pkg of 1 × 1 mg (860493P-1mg)
pkg of 1 × 10 mg (860493P-10mg)
manufacturer/tradenameAvanti Polar Lipids 860493P
运输dry ice
储存温度−20℃
SMILES stringC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC

安全信息

储存分类代码13 - Non Combustible Solids

Sigma-Aldrich

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