产品说明
一般描述
A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
包装
5 mg in Glass bottle
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Primary Target
caspase-1
Cell permeable: yes
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Reversible: no
警告
Toxicity: Irritant (B)
序列
Q-Val-Asp-CH₂-OPh
外形
Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C26H25F2N3O6 |
| 分子量 | 513.49 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥90% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
