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Gc-globulin from human plasma

Gc-球蛋白 来源于人类血浆

品牌
Sigma-Aldrich
CAS
68476-36-8
货号
G8764
规格纯度
≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
参考价格
3107.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.

应用

Gc-globulin from human plasma has been used:

  • as a fluorescent probe for G-actin staining
  • as a fluorescent probe to monitor steady-state rate of actin filament disassembly
  • as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)

Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.

生化/生理作用

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].

制备说明

Native Gc-globulin from human plasma

基本信息

MDL编号MFCD00131143
NACRESNA.61

产品性质

质量水平200
生物来源human plasma
测定≥90% (SDS-PAGE)
形式lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
分子量 ~52 kDa
technique(s)LC/MS: suitable
溶解性H2O: soluble 2 mg/mL
UniProt登记号P02774
储存温度−20℃
Gene Informationhuman ... GC(2638)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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