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Ras human

品牌
Sigma-Aldrich
货号
R9894
规格纯度
Wild type, recombinant, expressed in E. coli, buffered aqueous glycerol solution
参考价格
6002.62 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Ras proto-oncogene is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. The Ras gene is localized on human chromosome 11p15.5. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane.

应用

Human Ras has been used as a negative control in tubulin overlay assay.

生化/生理作用

Ras proteins, p21, are guanyl nucleotide binding proteins that play an important role in cellular signal transduction. Ras proteins are regulatory proteins that bind GTP in their active state. A Ras intrinsic GTPase activity hydrolyzes guanosine-5′-triphosphate (GTP) to guanosine diphosphate (GDP) thus inactivating Ras, while activation of Ras requires exchange of the bound GDP with GTP. Inhibition of Ras activity by stimulation of its GTPase activity is enhanced by GTPase activating proteins. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development, since abnormally active Ras is present in more than 50% of human cancers.

包装

Package size based on protein content

外形

Solution in 50% glycerol containing 50 mM Tris (pH 8.0), 5 mM MgCl2, 45 mM NaCl, 1 mM DTT

基本信息

MDL编号MFCD00241858
NACRESNA.32

产品性质

质量水平200
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式buffered aqueous glycerol solution
分子量 28 kDa
UniProt登记号Q0VAM2
运输dry ice
储存温度−70℃
Gene Informationhuman ... RASGEF1B(153020)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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