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Carbonic Anhydrase (CA) Activity Assay Kit (Colorimetric)

品牌
Sigma-Aldrich
货号
MAK404
规格纯度
sufficient for 100 colorimetric tests
参考价格
7113.43 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Carbonic anhydrases (CA) are zinc enzymes present in both prokaryotes and eukaryotes. They catalyze efficiently the reversible hydration of CO2 to bicarbonate. Their important patho-physiological roles in respiration, pH and CO2 homeostasis, secretion, gluconeogenesis, ureagenesis etc. make it an important drug target. Characteristic increase and decrease of CA Activity is observed in different physiological conditions and diseases such as anemia, Thalassemia, Hypothyroidism, Hyperthyroidism, and in several cases of lung and liver diseases and Leukemia.

特点和优势

Carbonic Anhydrase (CA) Activity Assay Kit:

  • Compatible with high-throughput handling systems.

适用性

The kit is suitable for the detection of carbonic anhydrase activity in hemolysates and serum, as well as the determination of enzymatic activity of purified CA.

原理

The assay utilizes the esterase activity of an active CA on an ester substrate which releases a chromophore.The released product can be easily quantified using a spectrophotometric multi-well plate reader. In the presence of a CA specific inhibitor, the enzyme loses its activity which results in a decrease of absorbance.To measure specific CA activity, the CA inhibitor Acetazolamide is included.Acetazolamide is a potent inhibitor of CA I, CA II, CA IV, CA IX, CA XII etc. except CA III.

产品性质

质量水平100
web metadata keyword.defaultCarbonic Anhydrase (CA) Activity Assay Kit (Colorimetric)|sigma-aldrich
detection methodcolorimetric
储存温度−20℃

安全信息

象形图GHS05GHS08
警示用语:Danger
危险声明H315 - H318 - H334
预防措施声明P261 - P264 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2
储存分类代码10 - Combustible liquids

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