Anti-Insulin-Like Growth Factor-I Receptor antibody produced in goat

产品说明

一般描述

Insulin-Like Growth Factor-I Receptor (IGF-I receptor) is a disulfide-linked heterotetrameric transmembrane protein that belongs to Tyr protein kinase family and is expressed mainly in all cells and tissues. Association of two α (130 kD) and two β (95 kD) subunits of IGF-I receptor is essential for receptor autophosphorylation. It has a pivotal role in cell growth control as well as can induce differentiation, and eventually cell death, of certain types of cells. Anti-Insulin-Like Growth Factor-I Receptor antibody can be used to block cell surface IGF-I sR mediated IGF-I and IGF-II bioactivity. Goat anti-Insulin-Like Growth Factor-I Receptor antibody reacts specifically with recombinant human IGF-I. The product has shown no cross-reactivity for other cytokines tested.

特异性

The antibody blocks cell surface IGF-I R mediated IGF-I and IGF-II biological activity. At optimal antibody concentration, no more than 40-60% of the IGF-I or IGF-II activity can be blocked by this antibody.

免疫原

Recombinant human IGF-I soluble receptor expressed in Sf 21.

应用

Anti-Insulin-Like Growth Factor-I Receptor antibody can be used in indirect ELISA and western blotting.

外形

Lyophilized from 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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