产品说明
一般描述
A highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα, βI, βII, γ, δ, and ε isozymes. May inhibit protein kinase A at a much higher concentration (Ki = 2 µM). Also inhibits telomerase A treated NPC-076 cells. A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
包装
1 ml in Glass bottle
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Target Ki: 10 nM against PKC
Reversible: yes
Primary Target
PKC
警告
Toxicity: Irritant (B)
外形
A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun.241, 730.
Gekeler, V., et al. 1996. Br. J. Cancer74, 897.
Kiss, Z., et al. 1995. Biochim. Biophys. Acta1265, 93.
Muid, R.E., et al. 1991. FEBS Lett.293, 160.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C25H24N4O2 |
| 分子量 | 412.48 |
| MDL编号 | MFCD00236428 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| InChI | 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChI key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - (refers to pure substance) |
| 闪点(C) | 87 ℃ - (refers to pure substance) |
