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InSolution Nutlin-3, Racemic-Calbiochem

品牌
Sigma-Aldrich
货号
444151
包装型号
规格纯度
参考价格
1709.38 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.

包装

1 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C30H30Cl2N4O4
分子量581.49

产品性质

质量水平100
测定≥98% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
运输wet ice
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

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