CA-074-Calbiochem

产品说明

一般描述

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC₅₀ = 2.24 nM for rat liver cathepsin B).
An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC₅₀ = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).

包装

1 mg in Plastic ampoule

生化/生理作用

Target IC₅₀: 2.24 nM for rat liver cathepsin B
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem.121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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