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InSolution GM 6001-Calbiochem

品牌
Sigma-Aldrich
货号
364206
规格纯度
InSolution GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 μl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs.
参考价格
1903.37 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
MMP-1
Target Ki: 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9

警告

Toxicity: Irritant (B)

外形

A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO.

重悬

Following initial use, aliquot and refrigerate (4°C).

其他说明

Solorzano, C.C., et al. 1997. Shock7, 427.
Galardy, R.E., et al. 1994. Ann. NY Acad. Sci.732, 315.
Galardy, R.E., et al. 1994. Cancer Res.54, 4715.
Galardy, R.E., et al. 1993. Drugs Future18, 1109.
Grobelny, D., et al. 1992. Biochemistry31, 7152.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H28N4O4
分子量388.46

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
运输wet ice
储存温度2-8℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

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