NanoFabTx^TM PEGylated nanoparticle formulation screening kit

产品说明

应用

NanoFabTx^™ PEGylated nanoparticle formulation screening kit is designed for the synthesis of specifically sized, hydrophobic drug encapsulated biodegradable PEGylated polymer nanoparticles. The kit contains rationally selected PEGylated PLGA, PLA, and PCL polymers that has been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules. This reagent kit can be combined with the NanoFabTx^™ Microfluidic - nano device kit (Cat.No. 911593) for microfluidic synthesis of PLGA nanoparticles.

PEGylated polymers used for synthesis result in nanoparticles with a PEG surface coating that reduces protein absorption and prolongs circulation time, leading to slow and sustained release of the encapsulated drug. The NanoFabTx^™ PEGylated nanoparticle formulation screening kit enables nanoparticle optimization by selection of the right polymer to achieve the desired nanoparticle size, drug encapsulation, release kinetics, and stability in systemic circulation. This kit provides reagents and protocols for nanoprecipitation and microfluidics to synthesize 60 nm to 100 nm nanoparticles.

特点和优势

• Step-by-step protocols developed and tested by our formulation scientists
• Microfluidic formulation development for enhancing drug bioavailability
• Flexible synthesis tool to create uniform and reproducible nanoparticles
• Choose from standard extrusion or microfluidic-based protocols
• Optimized to make nanoparticles from 60-100 nm

法律信息

NANOFABTX is a trademark of sigma-aldrich Co. LLC

产品性质