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InSolution Casein Kinase I Inhibitor, D4476-Calbiochem

品牌
Sigma-Aldrich
货号
218705
规格纯度
The InSolution Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2741.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).

包装

1 mg in Plastic ampoule
Packaged under inert gas
Please refer to vial label for lot-specific concentration.

生化/生理作用

Target IC50: 0.2 µM, 0.3 µM against CK1, CK1d, respectively
Primary Target
CK1, CK1d
Cell permeable: yes
Reversible: no
Product competes with ATP.

警告

Toxicity: Irritant (B)

外形

A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO

重悬

Following initial use, aliquot and refrigerate (4°C).

其他说明

Rena, G., et al. 2004. EMBO Reports5, 60.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C23H18N4O3
分子量398.41

产品性质

质量水平100
测定≥95% (LC/MS)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
运输wet ice
储存温度−20℃

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