应用
Phenyl chlorothionoformate has been used in stereo directed synthesis of optically active, (-)-mintlactone, synthesis of peptide α-thioesters having a variety of C-terminal amino acids, synthesis of scyllo-inositol derivatives, thionocarbonylation of unprotected thymine nucleosides, preparation of phenoxythiocarbonyl esters of protected ribonucleosides. It is also used as a reagent in the thionocarbonylation of unprotected thymine nucleosides. It forms phenoxythiocarbonyl esters of protected ribonucleosides which can be reduced by tributyltin hydride to deoxyribonucleosides.
备注
Moisture, Heat Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.
基本信息
MDL
MFCD00004920
EINECS
213-736-4
分子式
C7H5ClOS
分子量
172.63
沸点
81-83°/6mm
闪点
81°(177°F)
密度
1.248
折射率
1.5804
灵敏度
Keep Cold. Moisture Sensitive. Store under Nitrogen.
形态
Liquid
溶解性
Soluble in water.
Beilstein
774830
GHS危害和防范说明
GHS符号
Hazard Statements
H227-H314-H318
Combustible liquid.Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements
P280-P305+P351+P338-P309-P310
Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF exposed or if you feel unwell:Immediately call a POISON CENTER or doctor/physician.
安全信息
危险等级
8
包装组
II
危险类别
34
Causes burns.
安全等级
20-23-26-36/37/39-45-60
When using do not eat or drink.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste
欧盟危险品标志
TSCA
否
