应用
Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.
备注
Incompatible with acids, bases, oxidizing agents and reducing agents.
基本信息
MDL
MFCD00001893
EINECS
219-806-0
分子式
C6H12NO3P
分子量
177.14
沸点
132-135°/1.2mm
闪点
>110°(230°F)
密度
1.094
折射率
1.4330
灵敏度
Ambient temperatures.
形态
Liquid
溶解性
Miscible with water, chloroform, terahydrofuran, ethyl acetate and methylene chloride.
Beilstein
1772981
GHS危害和防范说明
GHS符号
Hazard Statements
H302-H312-H331-H315-H319
Harmful if swallowed.Harmful in contact with skin.Toxic if inhaled.Causes skin irritation.Causes serious eye irritation.
Precautionary Statements
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险等级
6.1
包装组
III
危险类别
20/21/22-36/38
Harmful by inhalation, in contact with skin and if swallowed.Irritating to eyes and skin.
安全等级
9-23-26-36/37-60
Keep container in a well-ventilated place.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.This material and its container must be disposed of as hazardous waste
欧盟危险品标志
TSCA
否
