产品说明
一般描述
3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a major metabolite of furan fatty acids, is a uremic toxin (UT), excreted into the urine via organic,anion transporters under physiological conditions. It is mostly reported to be accumulated in chronic kidney disease (CKD) patients. Monitoring of CMPF may be important to predict organic anion transporting polypeptide (OATP)1B activity in CKD patients as studies have implicated a decreased trend in (OATP)1B activity in patients with this uremic toxin. It is also found to be in increased concentrations, for patients who progress from prediabetes to type 2 diabetes, patients with renal failure, polyunsaturated fatty acids with high-temperature cooking and subjects who consume fish or fish oil.
应用
3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid may be used as an analytical reference standard for the quantification of the analyte in human plasma samples using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS).
基本信息
| 经验(实验)分子式 | C12H16O5 |
| 分子量 | 240.25 |
| MDL编号 | MFCD08436079 |
| NACRES | NB.21 |
产品性质
| 等级 | analytical standard |
| 质量水平 | 100 |
| 测定 | ≥95.0% (HPLC) |
| 保质期 | limited shelf life, expiry date on the label |
| application(s) | clinical testing |
| 格式 | neat |
| 储存温度 | 2-8℃ |
| SMILES string | OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O |
| InChI | 1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16) |
| InChI key | WMCQWXZMVIETAO-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
