产品说明
一般描述
Chemical structure: aminoglycoside
应用
Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).
生化/生理作用
Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.
Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.
Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.
包装
10ml
制备说明
This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8℃.
其他说明
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
基本信息
| 经验(实验)分子式 | C21H39N7O12 · 1.5H2SO4 |
| 分子量 | 728.69 |
| MDL编号 | MFCD00037023 |
| PubChem化学物质编号 | 329769423 |
| NACRES | NA.24 |
产品性质
| 质量水平 | 100 |
| 等级 | analytical standard |
| 形式 | liquid |
| 浓度 | ~1 mg/mL in 1 mM EDTA |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| 颜色 | colorless |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria mycobacteria |
| application(s) | pharmaceutical (small molecule) |
| 格式 | single component solution |
| 作用机制 | protein synthesis | interferes |
| 储存温度 | 2-8℃ |
| SMILES string | OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N |
| InChI | 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1 |
| InChI key | QTENRWWVYAAPBI-YZTFXSNBSA-N |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves |
