产品说明
一般描述
Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.
生化/生理作用
Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.
附注
To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.
基本信息
| 经验(实验)分子式 | C20H28N2O5S · HCl |
| 分子量 | 444.97 |
| MDL编号 | MFCD00922997 |
| PubChem化学物质编号 | 329823437 |
产品性质
| 质量水平 | 300 |
| 等级 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| 包装 | ampule of 1 × 200 mg |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | pharmaceutical (small molecule) |
| 格式 | neat |
| 药典可追溯性 | traceable to BP 876 traceable to PhEur Y0000650 traceable to USP 1643260 |
| 储存温度 | -10 to -25℃ |
| SMILES string | Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O |
| InChI | 1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1 |
| InChI key | ZZIZZTHXZRDOFM-XFULWGLBSA-N |
| Gene Information | human ... ADRA1A(148), ADRA1B(147), ADRA1D(146) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 预防措施声明 | P264 - P270 - P301 + P312 - P501 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
