产品说明
一般描述
嘌呤核苷酸生物合成中咪唑核苷酸中间体的类似物。
Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.
生化/生理作用
用于抵御多种人类病毒感染的抗病毒剂，特别是慢性肝炎C、HIV 和腺病毒。其代谢产物利巴韦林 5′-磷酸，是肌苷一磷酸 (IMP) 脱氢酶的抑制剂，但也有实验证据支持许多其他作用机制。
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.
基本信息
| 经验(实验)分子式 | C8H12N4O5 |
| 分子量 | 244.20 |
| MDL编号 | MFCD00058564 |
| PubChem化学物质编号 | 329823563 |
产品性质
| 质量水平 | 300 |
| 等级 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| 包装 | pkg of 1 g |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | pharmaceutical (small molecule) |
| 格式 | neat |
| 药典可追溯性 | PhEur traceable to BP 593 traceable to USP 1602706 |
| 储存温度 | 2-8℃ |
| SMILES string | NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O |
| InChI | 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 |
| InChI key | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
| Gene Information | human ... IMPDH1(3614) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H341 - H360FD |
| 预防措施声明 | P201 - P308 + P313 |
| 危险分类 | Muta. 2 - Repr. 1B |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
