产品说明
一般描述
Praziquantel is at present the only drug used for the treatment of human schistosomiasis. It has a pyrazino isoquinoline ring system and is found to be very successful in animals for its anticestode and antitrematode properties. It has been identified that the voltage-gated schistosome calcium ion (Ca2+) channels serve as a target for praziquantel. Even though the commercial preparation of praziquantel comprises of equal amounts of both its ‘dextro′ and ‘laevo′ isomers, only the ‘laevo′ form exhibits schistosomicidal activity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Praziquantel may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by electrochemical, spectrophotometric, and chromatographic techniques.
附注
To see an example of a Certificate of Analysis for this material enter LRAA1898 in the slot below. This is an example certificate only and may not be the lot that you receive.
基本信息
| 经验(实验)分子式 | C19H24N2O2 |
| 分子量 | 312.41 |
| Beilstein | 761557 |
| EC 号 | 259-559-6 |
| MDL编号 | MFCD00058531 |
| PubChem化学物质编号 | 329823365 |
| NACRES | NA.24 |
产品性质
| 质量水平 | 300 |
| 等级 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | pharmaceutical (small molecule) |
| 格式 | neat |
| 药典可追溯性 | traceable to PhEur P2670000 traceable to USP 1554603 |
| 储存温度 | 2-8℃ |
| SMILES string | O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4 |
| InChI | 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2 |
| InChI key | FSVJFNAIGNNGKK-UHFFFAOYSA-N |
安全信息
| 危险声明 | H412 |
| 预防措施声明 | P273 |
| 危险分类 | Aquatic Chronic 3 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
