Technical Notes:
1. Biaryl bisphosphine ligand. The Ha-BINAP ligand, as the ruthenium complex, catalyzes hydrogenation of unsaturated carboxylic acids to a higher ee than does BINAP. (Ref. 1,2)
2.The ruthenium catalyzed hydrogenation of aryl propenoic acid to produce the drug Ibuprofen.
References:
1. J. Org. Chem., 1996, 61, 5510.
2. Topics Organometal. Chem. 2004, 6, 63 (review).