Technical Notes:
1.See 15-0066.
2.Biaryl bisphosphine ligand with narrow dihedral angle. The DTBM SEGPHOS ligand, as the ruthenium complex, gives superior enantioselectivity and diastereoselectivity through dynamic kinetic resolution in the asymmetric hydrogenation of a-substituted-ß-ketoesters useful in the synthesis of carbapenum antibiotics.
References:
1. Adv. Synth. Cat., 2001, 343, 264.