Technical Notes:
1. Biaryl bisphosphine ligand with narrow dihedral angle. The DTBM SEGPHOS® ligand, as the
ruthenium complex, gives superior enantioselectivity and diaste reoselectivity through dynamic kinetic resolution in the asymmetric hydrogenation of a-substituted-ß-ketoesters useful in the synthesis of carbapenum antibiotics.
2. With rhodium, preferential enantioselective hydrogenation of more reactive olefin of extended enone structure .
3.Rhodium catalyzed chemo-, regio, and entantioselective 2 + 2 + 2 cycloaddition of alkynes with isocyanates .
4.With copper, enantioselective cross Aldol-type reaction of acetonitrile.4
5.With copper, enantioselective vinylsilane alkenylation of aldehydes .5
6.Gold carbene mediated stereoselective cyclopropanation of propargyl esters.
7.With copper, enantioselective 1,2 -reduction of ketones, and 1 ,4-reduction of a a,ß-usaturatedesters.
8.With copper, catalytic enantioselective Mannich-type reaction.
9.Enantioselective fluorination of b ß-keto esters, tert- butoxycarbonyl lactones and lactmes with Sodeoka's Pd-aqua complex and a fluorinating reagent.
10.Rh-catalyzed intramolecular olefin or carbonyl hydroacylation. 10
11.Pd-catalyzed y-arylation of ß,y-unsaturated ketones.
12Involved in numerous conjugate alkynylation, and ring-opening alkynylation of
azabenzonorbornadienes.
13.Involved in asymmetric hydroamination of bicyclic alkenes/die nes, 13a diamination of conjugated dienes,sb and hydroalkoxylation/hydrosulfenylation of allenes.se
14.Used in cycloaddition reactions such as 1,3-dipolar cycloaddition of azomethine ylides, and Au-catalyzed 2 +2 cycoaddition of allenes.
15.Asymmetric conjugate addition of nitroalkanes to a,ß-usaturated thioamides.
16.Asymmetric synthesis of isothiazoles through Cu catalyzed conjugate addition of allyl cyanide to a,ß-usaturated thioamides .
17.Asymmetric Ag-catalyzed cycloadditions."
18.Rhodium-catalyzed c c bond cleavage to generate acyclic, asymmetric quaternary centers.
19.Iridium-catalyzed intermolecular hydroamidation of olefins .
20.Iridium-catalyzed intermolecular hydroamidation of olefins.
21.CuH-catalyzed asymmetric hydroamination of olefins.
