产品说明
一般描述
Timeless is a highly conserved protein that modulates cell survival and morphogenesis. It is also involved in enhancing DNA polymerase functions and the maintenance of telomere length. Studies have revealed that TIMELESS modulates phase advancing of the circadian clock in response to DNA damage. Furthermore, it has been implicated in carcinogenesis.
Rabbit Anti-TIMELESS antibody recognizes canine, human, mouse, rat, and bovine TIMELESS.
免疫原
Synthetic peptide directed towards the N terminal region of human TIMELESS
应用
Rabbit Anti-TIMELESS antibody can be used for western blot applications at a concentration of 0.25 μg/ml. It can also be used for IHC assays at 4-8 μg/ml.
生化/生理作用
The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
序列
Synthetic peptide located within the following region: IGERDLIFHKGLHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRSALNVR
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 139 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_003911 |
| UniProt登记号 | Q9UNS1 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TIMELESS(8914) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
