产品说明
一般描述
Solute carrier family 45, member 2/melanoma antigen AIM1/membrane-associated transporter protein (SLC45A2, 1A1, AIM1, MATP) is a skin pigmentation protein involved in melanin biosynthesis. SLC45A2 is a melanoma-associated protein. Defective MATP is a cause of the hypopigmention condition oculocutaneous albinism type 4 (OCA4).
特异性
Anti-SLC45A2 polyclonal antibody reacts with human, mouse, rat, pig, bovine, and canine solute carrier family 45, member 2 proteins.
免疫原
Synthetic peptide directed towards the C terminal region of human SLC45A2
应用
Anti-SLC45A2 polyclonal antibody is used to tag solute carrier family 45, member 2 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of solute carrier family 45, member 2 in melanin biosynthesis, pigmentation and melanoma development.
生化/生理作用
SLC45A2 is a melanocyte differentiation antigen that is expressed in a high percentage of melanoma cell lines. A similar sequence gene in medaka, ′B,′ encodes a transporter that mediates melanin synthesis. Mutations in this gene are a cause of oculocutaneous albinism type 4.The protein encoded by this gene encodes a melanocyte differentiation antigen that is expressed in a high percentage of melanoma cell lines. A similar sequence gene in medaka, ′B,′ encodes a transporter that mediates melanin synthesis. Mutations in this gene are a cause of oculocutaneous albinism type 4. Alternative splicing results in multiple transcript variants encoding different isoforms.
序列
Synthetic peptide located within the following region: IGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFC
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 51 kDa |
| species reactivity | human, rat |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_057264 |
| UniProt登记号 | Q6P2P0 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SLC45A2(51151) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
