产品说明
一般描述
SKIIP (SNW1) belongs to the SNW gene family and codes for a co-activator that facilitates transcription. In vertebrate embryos, SNW1 is known to modulate spatial BMP functions, neural crest specifications and neural plate synthesis.
Rabbit Anti-SKIIP recognizes mouse, canine, human, bovine, and rat SKIIP.
免疫原
Synthetic peptide directed towards the N terminal region of human SKIIP
应用
Rabbit Anti-SKIIP can be used for western blot applications at a concentration of 1-5μg/ml. It can also be used for IHC at 4-8μg/ml, using paraffin-embedded tissues.
生化/生理作用
SKIIP (Nuclear Protein SkiP, nuclear receptor coactivator NCoA-62, ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
序列
Synthetic peptide located within the following region: RQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALE
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 61 kDa |
| species reactivity | bovine, mouse, horse, rabbit, rat, human, pig, dog |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_036377 |
| UniProt登记号 | Q13573 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SKIIP(22938) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
