产品说明
一般描述
40S ribosomal protein S6 (also known as RPS6) is a ∼31kDa substrate of p70 S6 kinase (p70S6K) and a major component of translational machinery involved in protein synthesis, cell growth, proliferation, and metabolism. RPS6 undergoes phosphorylation on multiple serines in the carboxyl terminal region in the order 236→235→240→244→247, due to the positions of these amino acid residues on the alpha-helix. Hyperphosphorylation of RPS6 stimulates protein synthesis that mediates progression through the cell cycle.
The RPS6 (ribosomal protein S6) gene is mapped to human chromosome 9p22.1.
免疫原
Synthetic peptide derived from the region of human S6 ribosomal that contains phosphorylated serines 235 and 236.
应用
Anti-S6 ribosomal protein (phospho S235/236) antibody, Rabbit monoclonal has been used in Western Blotting.
生化/生理作用
The RPS6 (ribosomal protein S6) protein is involved in the 40S subunit assembling. RpS6 might be involved in the regulation of cellular metabolism, the size of cells, their proliferation and survival. RpS6 might stimulate or inhibit translation of certain mRNA. Upregulation of the gene is observed in pulmonary sclerosing hemangioma, lymphangioleiomyomatosis-associated angiomyolipomas, dysplasia, oral cavity and esophageal squamous cell carcinoma.
特点和优势
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外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 重组 | expressed in proprietary host |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | SP50, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | rat, bovine, chicken, mouse, dog, frog, pig, rabbit |
| technique(s) | immunohistochemistry: 1:100 |
| 同位素/亚型 | IgG |
| UniProt登记号 | P62753 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... RPS6(6194) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
