产品说明
一般描述
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 (PSMD11) is a non-ATPase subunit of the 19S regulator complex which together with the 20S core complex make up the multicatalytic proteinase complex know as the 26S proteosome.
特异性
Rabbit polyclonal anti-PSMD11 (AB1) antibody reacts with bovine, canine, zebrafish, zebrafish, human, mouse, and rat 26S proteasome non-ATPase regulatory subunit 11 subunits.
免疫原
Synthetic peptide directed towards the C terminal region of human PSMD11
应用
Rabbit polyclonal anti-PSMD11 (AB1) antibody is used to tag 26S proteasome non-ATPase regulatory subunit for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of 26S proteasome non-ATPase regulatory subunit in the structure and function of the 19S regulator complex of the 26S proteosome.
生化/生理作用
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.
序列
Synthetic peptide located within the following region: ALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAK
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 47 kDa |
| species reactivity | human, mouse, guinea pig, bovine, rat, dog, yeast, horse, rabbit |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_002806 |
| UniProt登记号 | O00231 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PSMD11(5717) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
