产品说明
一般描述
Maxi-K channels, also known as BK channels, consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher calcium sensitivity. Homologs of the Drosophila melanogaster calcium-activated potassium channel gene, slowpoke, the mouse and human genes generate multiple transcripts by alternative splicing. The splice variants differ significantly in their Ca2+ sensitivity, suggesting a broad functional role for these channels in the regulation of neuronal excitability. The alpha-subunit shows a tissue distribution different to that of the beta-subunit, and in many tissues there may be no association of alpha-subunits with beta-subunits. The beta-subunits can play a functional role in the regulation of neuronal excitability by tuning the Ca2+ and/or the voltage dependence of alpha-subunits (Tseng-Crank et al., 1996). Maxi-K channels may have potential utility of gene therapy for urinary incontinence and erectile dysfunction.
免疫原
Synthetic 17 amino acid peptide from C-terminus of human PPYR1. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Panda (94%); Monkey, Bovine, Horse, Pig (88%); Bat, Rabbit (82%).
特点和优势
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外形
Supplied at 1 mg/ml
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 4-6 μg/mL |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PPYR1(5540) |
安全信息
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
