产品说明
一般描述
NUP88 (Nucleoporin 88kDa) is an 88kDa non-FG nucleoporin. It acts as a component of a novel nuclear pore complex (NPC). It consists of a C-terminal coiled-coil domain and an interaction domain. It is localized in the cytoplasmic surface of nuclear pore complexes (NPCs). NUP88 consists of two domains, N-terminal and C-terminal domains and its N-terminal and C-terminal domains have been predicted to form β-propeller and a coiled-coil domain.
应用
ANTI-NUP88 (C-TERM) antibody produced in rabbit is suitable for western blot analysis at a dilution of 1:250-1:500.
生化/生理作用
NUP88 (Nucleoporin 88kDa) participates in trafficking between the nucleus and cytoplasm. Its N-terminal β-propeller domain interacts with the FG (phenylalanine-glycine) repeat domain of nucleoporin CAN/Nup214. Further, it binds directly to CRM-1/exportin-1, the receptor for export of most proteins from the nucleus. Nup88 also possesses the ability to bind to the other FG nucleoporins Nup358 and Nup98. Overexpression of NUP88 has been observed in several types of malignancies such as colorectal cancer (CRC) and breast cancer cells.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 83542 Da |
| species reactivity | human |
| technique(s) | western blot: 1:1000 |
| NCBI登记号 | NP_002523.2 |
| UniProt登记号 | Q99567 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
