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Anti-MCM4 (AB1) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV36649
规格纯度
IgG fraction of antiserum
参考价格
3311.54 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

MCM4 is a component of the mini-chromosome maintenance (MCM) complex. This complex is critical for the formation of the pre-replication complex required for replication initiation. The complex functions as a DNA helicase. MCM4 is found expressed in the nucleus with a molecular weight of 96 kDa.

免疫原

Synthetic peptide directed towards the middle region of human MCM4

生化/生理作用

The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. The MCM4 gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.

序列

Synthetic peptide located within the following region: VYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYE

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 95 kDa
species reactivitymouse, bovine, dog, guinea pig, horse, human, rat, rabbit
浓度0.5 mg - 1 mg/mL
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_877423
UniProt登记号P33991
运输wet ice
储存温度−20℃
Gene Informationhuman ... MCM4(4173)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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