产品说明
一般描述
HIV-1 Tat interactive protein 2, 30 kDa (HTATIP2, CC3, TIP30) is an HIV-1 Tat interacting protein that acts as a tumor suppressor via the repression of genes involved in proliferation and apoptosis. HTATIP2/TIP30 can act as a repressor of ERα-mediated c-Myc transcription in mammary glands and breast cancer cells and inhibit estrogen receptor-mediated transcription in mammary epithelial cells (MEC). HTATIP2/TIP30 controls endocytic downregulation of the EGFR signaling pathway in primary hepatocytes and hepatocellular carcinoma cells.
Aspirin-induced upregulation of HTATIP2 is known to improve survival in hepatocellular carcinoma. Sorafenib-induced downregulation of HTATIP2 promotes cellular invasion and metastasis in mouse models of hepatocellular cancer.
Rabbit Anti-HTATIP2 (AB2) antibody recognizes rat, bovine, mouse, human, and canine HTATIP2.
Rabbit polyclonal anti-HTATIP2 antibody reacts with rat, bovine, mouse, human, and canine HIV-1 Tat interactive protein 2, 30 kDa proteins.
免疫原
Synthetic peptide directed towards the N terminal region of human HTATIP2
应用
Rabbit polyclonal anti-HTATIP2 antibody is used to tag HIV-1 Tat interactive protein 2 detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of HIV-1 Tat interactive protein 2 in the regulation of genes involved in tumor proliferation, cell proliferation and apoptosis.
Rabbit Anti-HTATIP2 (AB2) antibody can be used for rat, bovine, mouse, human, and canine HTATIP2.
生化/生理作用
CC3 (HTATIP2) is a member of the short-chain dehydrogenases/reductases (SDR) family. It is a novel serine/threonine kinase that phosphorylates the C-terminal domain (CTD) of the largest RNA polymerase II subunit and induces the expression of apoptosis related genes Bad and Siva, as well as metastasis suppressor NM23-H2. It also interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates ERalpha-mediated c-myc transcription.
序列
Synthetic peptide located within the following region: TGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYA
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 27 kDa |
| species reactivity | dog, rat, rabbit, bovine, mouse, guinea pig, horse, human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_006401 |
| UniProt登记号 | O15383 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... HTATIP2(10553) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
