产品说明
一般描述
Growth hormone 2 (GH-V), a member of the growth hormone/placental lactogen (GH/PL) gene cluster, is an isoform of growth hormone produce mainly in the placenta as opposed to the pituitary expressed GH-N. Both GH-V and GH-N interact, differentially, with the two growth hormone receptors.
特异性
Anti-GH2 polyclonal antibody reacts with human, mouse, rat, rabbit growth hormone-2 (GH-V) proteins.
免疫原
Synthetic peptide directed towards the middle region of human GH2
应用
Anti-GH2 polyclonal antibody is used to tag growth hormone-2 (GH-V) proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the differential roles of growth hormone-2 (GH-V) versus GH-N at the level of growth-hormone binding and function within tissues.
生化/生理作用
GH2 is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Mutations in its gene lead to placental growth hormone/lactogen deficiency.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.
序列
Synthetic peptide located within the following region: NQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSC
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 22 kDa |
| species reactivity | mouse, sheep, horse, goat, human, pig, bovine, rat, rabbit |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_072050 |
| UniProt登记号 | O14643 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GH2(2689) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
