产品说明
一般描述
Gem/Kir, a Rad/Rem/Gem/Kir (RGK) GTPases family member, is a small GTP-binding protein involved in the regulation (inhibition) of high voltage-activated (HVA) Ca2+ channels, such as the P/Q-Type Ca2+ channels, that modulate neural, endocrine and muscle functions.
特异性
Anti-GEM polyclonal antibody reacts with bovine, human, mouse, rat, canine, and chicken Gem/Kir GTPase proteins.
免疫原
Synthetic peptide directed towards the C terminal region of human GEM
应用
Anti-GEM polyclonal antibody is used to tag Gem/Kir GTPase proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of Gem/Kir as inhibitors of high voltage-activated (HVA) Ca2+ channels within neural, endocrine and muscle tissues.
生化/生理作用
GEM belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction.The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
序列
Synthetic peptide located within the following region: ETSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRKESMPRKARRFW
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 33 kDa |
| species reactivity | human, bovine, rabbit, rat, mouse, dog, horse, guinea pig |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_859053 |
| UniProt登记号 | P55040 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GEM(2669) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
