产品说明
一般描述
GATAD2B codes for a GATA zinc finger domain containing protein that forms a part of the MeCP1-Mi-2/nucleosome remodeling and deacetylase complex. Studies in Drosphila have reported that GATAD2B is required in neurons for cognitive functions and synaptic development. GATAD2B loss-of-function mutation has been associated with intellectual disabilities.
Rabbit Anti-GATAD2B antibody recognizes canine, zebrafish, bovine, human, mouse, and rat GATAD2B.
免疫原
Synthetic peptide directed towards the N terminal region of human GATAD2B
应用
Rabbit Anti-GATAD2B antibody is suitable for western blot applications at a concentration of 0.25 μg/ml.
生化/生理作用
Hp66beta (GATAD2B), previously identified as a component of the human MeCP1 complex, is a second member of a p66 gene family (hp66alpha and hp66beta). Both proteins interact with MBD2 and MBD3 functionally and biochemically. Both factors function in synergy, since knocking-down p66alpha affects the repressive function of p66beta and vice versa. Furthermore, confocal microscopy shows a nuclear colocalization of hp66alpha with hp66beta and MBD2 in a speckled pattern. These two highly related mammalian p66 proteins display overlapping functions and are involved in methylation dependent transcriptional repression.
序列
Synthetic peptide located within the following region: MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLK
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 65 kDa |
| species reactivity | bovine, human, mouse, rabbit, guinea pig, rat, horse, dog |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_065750 |
| UniProt登记号 | Q8WXI9 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GATAD2B(57459) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
