产品说明
免疫原
Synthetic peptide directed towards the N terminal region of human FKBP8
应用
Anti-FKBP8 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
生化/生理作用
FKBP8 gene encodes for FK506 binding protein 8, which is a membrane-anchored, tetratricopeptide repeat (TPR)-containing immunophilin that belongs to peptidylprolyl isomerase family and facilitates the cis/trans interconversion of peptidyl prolyl bonds. It also regulates the late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability. FKBP38 plays a crucial role in regulating the apoptosis as well as the function of Bcl-2. Overexpression of FKBP38 diminishes the reduction rate of Bcl-2 that leads to increase in intracellular Bcl-2 level and inhibits the apoptotic cell death. Further, FKBP8 directly interacts with the flexible loop domain of Bcl-2 that contains the caspase cleavage site and protects Bcl-2 from caspase-dependent degradation.
序列
Synthetic peptide located within the following region: GPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLS
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 45 kDa |
| species reactivity | mouse, dog, goat, human, horse, rat, guinea pig |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_036313 |
| UniProt登记号 | Q14318 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... FKBP8(23770) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
