Anti-EPS15 antibody produced in rabbit

产品说明

一般描述

EPS15 gene encodes a protein, which is a tyrosine kinase substrate and is expressed ubiquitously. It is mapped to chromosome 1p31-p32 with three N-terminal conserved EH protein-protein interaction domains, a central coiled-coil region, and a C-terminal domain containing the AP-2 and AP-1 binding domains. The C-terminal domain also contains two ubiquitin interaction motifs (UIMs), required for Eps15 binding to ubiquitin.

免疫原

Synthetic peptide directed towards the C terminal region of human EPS15

应用

Anti-EPS15 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

生化/生理作用

The encoded protein is an adaptor protein that plays a pivotal role in the clathrin mediated internalization and degradation of EGFR (epidermal growth factor receptor). It also regulates the endosomal trafficking of EGFR, possibly through the recruitment of the ubiquitinated receptors to the rims of clathrin-coated pits. Additionally, Dab2 recruits EPS15 protein and facilitates the internalization of integrin β1.

序列

Synthetic peptide located within the following region: LDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNF

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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