产品说明
一般描述
Docking protein 3 (DOK3) is an adaptor molecule encoded by the gene mapped to human chromosome 5q35.3. The encoded protein belongs to the downstream of tyrosine kinase (Dok) protein family. DOK3 is predominantly expressed in various hematopoietic cell types, including B cells and macrophages.
免疫原
The antiserum was produced against synthesized peptide derived from human DOK3.
Immunogen Range: 101-150
生化/生理作用
Docking protein 3 (DOK3) along with DOK1 and DOK2 acts in negative feedback signaling loops to regulate tyrosine kinase signaling. DOK3 recruits inhibitory molecules, which might be involved in the negative regulation of immunoreceptor signaling in hematopoietic cells including, B cells and macrophages. In addition, the encoded protein stimulates interferon (IFN)-β production via facilitating tumor necrosis factor receptor associated factor 3 (TRAF3)/ TANK-binding kinase 1 (TBK1) complex formation and interferon regulatory transcription factor-3 (IRF-3) activation.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 53 kDa |
| species reactivity | human, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 western blot: 1:500-1:1000 |
| NCBI登记号 | Q7L591 |
| UniProt登记号 | Q7L591 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... DOK3(79930) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
