产品说明
一般描述
CRSP6 (MED17) is a subunit of the CRSP (cofactor required for SP1 activation) complex which interacts with TFIID and SP1 to mediate transcriptional initiation. MED17 mutations have been linked to infantile cerebral and cerebellar atrophy.
Rabbit Anti-CRSP6 antibody recognizes chicken, rat, mouse, human, canine, and bovine CRSP6.
免疫原
Synthetic peptide directed towards the N terminal region of human CRSP6
应用
Rabbit Anti-CRSP6 antibody can be used for western blot applications at 0.5 μg/ml. It can also be used for IHC of paraffin-embedded tissues at 4-8 μg/ml.
生化/生理作用
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
序列
Synthetic peptide located within the following region: AAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILG
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 73 kDa |
| species reactivity | guinea pig, rat, bovine, dog, rabbit, horse, human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | ChIP: suitable immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_004259 |
| UniProt登记号 | Q9NVC6 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CRSP6(9440) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
